Product Name: TAK-044
Description: TAK-044 is an Endothelin receptor antagonist. TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. TAK-044 showed protective effect on neuronal cell viability in in vitro oxygen-glucose deprivation model of strok
CAS NO: 1239358-85-0 Product: NS-018 (hydrochloride)
Synonym: TAK-044; TAK 044; TAK044.
IUPAC Chemical Name: sodium 2,2-((2R,5R,8S,11S,14R,17R)-17-((1H-indol-3-yl)methyl)-14-isobutyl-3,6,9,12,15,18-hexaoxo-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-11-(thiophen-2-yl)-1,4,7,10,13,16-hexaazacyclooctadecane-2,8-diyl)diacetate
In ChiKey: UWHBIISPHYTOGL-KGKYADQVSA-L5-Lipoxygenase inhibitors
SMILE Code: O=C(N1CCN(C2=CC=CC=C2)CC1)C[C@H](C(N[C@@H](CC([O-])=O)C(N[C@H](C3=CC=CS3)C(N[C@H](CC(C)C)C(N[C@@H]4CC5=CNC6=C5C=CC=C6)=O)=O)=O)=O)NC([C@@H](CC([O-])=O)NC4=O)=O.[Na+].[Na+]
Appearance: Solid powder
Purity: 98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Medchemexpress.com
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: 2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22147939
Chemical Formula：C45H51N9Na2O11S
ExactMass:
Molecular Weight: 971.9945
Elemental Analysis: C, 55.61; H, 5.29; N, 12.97; Na, 4.73; O, 18.11; S, 3.30
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