Espir. Crit. Care Med. 28, 17181 (2007). 3. Openshaw, P.J. Tregoning, J.S. Immune responses and disease enhancement for the duration of respiratory syncytial virus infection. Clin. Microbiol. Rev. 18, 54155 (2005). four. Moghaddam, A. et al. A prospective molecular mechanism for hypersensitivity attributable to formalin-inactivated vaccines. Nat. Med. 12, 90507 (2006). 5. Delgado, M.F. et al. Lack of antibody affinity maturation as a result of poor Toll-like receptor stimulation results in enhanced respiratory syncytial virus illness. Nat. Med. 15, 341 (2009). six. Lukacs, N.W., Smit, J.J., Mukherjee, S., Morris, S.B., Nunez, G. Lindell, D.M. Respiratory virus-induced TLR7 activation controls IL-17-associated enhanced mucus by way of IL-23 regulation. J. Immunol. 185, 2231239 (2010). 7. Mukherjee, S. et al. IL-17-induced pulmonary pathogenesis in the course of respiratory viral infection and exacerbation of allergic illness. Am. J. Pathol. 179, 24858 (2011). 8. Parrish-Novak, J. et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408, 573 (2000). 9. Coquet, J.M. et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol. 178, 2827834 (2007). 10. Chtanova, T. et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their function as non-Th1/Th2 effector cells that give enable for B cells. J. Immunol. 173, 688 (2004). 11. Wei, L., Laurence, A., Elias, K.M. O’Shea, J.J IL-21 is produced by Th17 cells and drives IL-17 production within a STAT3-dependent manner. J. Biol. Chem. 282, 346054610 (2007). 12. Spolski, R. Leonard, W.J Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26, 579 (2008). 13. Monteleone, G. et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 55, 1774780 (2006). 14. Suto, A. et al. Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells. Blood 100, 4565573 (2002). 15. Kasaian, M.T. et al. IL-21 limits NK cell responses and promotes antigenspecific Tcell activation: a mediator of your transition from innate to adaptive immunity. Immunity 16, 55969 (2002). 16. Fantini, M.C. et al. IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur. J. Immunol. 37, 3155163 (2007). 17. Peluso, I. et al. IL-21 counteracts the regulatory T cell-mediated suppression of human CD4 T lymphocytes. J. Immunol. 178, 73239 (2007). 18. Caruso, R. et al. A functional part for interleukin-21 in advertising the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.Evofosfamide Purity & Documentation Gastroenterology 132, 16675 (2007).Protopine Neuronal Signaling VOLUME 6 Number four | JULY 2013 | www.PMID:24458656 nature/miARTICLES19. Wurster, A.L. et al. Interleukin 21 is really a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J. Exp. Med. 196, 96977 (2002). 20. Strengell, M., Sareneva, T., Foster, D., Julkunen, I. Matikainen, S. IL-21 up-regulates the expression of genes linked with innate immunity and Th1 response. J. Immunol. 169, 3600605 (2002). 21. Nurieva, R. et al. Crucial autocrine regulation by IL-21 within the generation of inflammatory T cells. Nature 448, 48083 (2007). 22. Korn, T. et al. IL-21 initiates an option pathway to induce proinflammatory T(H)17 cells. Nature 448, 48487 (2007). 23. Tama.
bet-bromodomain.com
BET Bromodomain Inhibitor