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. Nat Rev Immunol 2003; three: 235. 12 Soleimani M, Nadri S. A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protocols 2009; 4: 10206. 13 Zhang X, Goncalves R, Mosser DM. The isolation and characterization of murine macrophages. Curr Protocols Immunol 2008. Chapter 14: Unit 14 1. 14 Weischenfeldt J, Porse B. Bone marrow-derived macrophages (BMM): isolation and applications. CSH Protocols 2008; 3: 1. 15 Kim J, Hematti P. Mesenchymal stem cell-educated macrophages: a novel kind of alternatively activated macrophages. Exp Hematol 2009; 37: 1445453.MSCs reciprocally regulate the M1/M2 balance D-I Cho et al16 Beda N, Nedospasov A. A spectrophotometric assay for nitrate in an excess of nitrite. Nitric Oxide Biol Chem 2005; 13: 937. 17 Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 2010; 121: 2437445. 18 Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E et al. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol 2010; 55: 1629638. 19 Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol 2012; 59: 15363. 20 Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW et al. Speedy monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med 2012; 209: 12337. 21 Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 3037047. 22 Adutler-Lieber S, Ben-Mordechai T, Naftali-Shani N, Asher E, Loberman D, Raanani E et al. Human macrophage regulation through interaction with cardiac adipose tissue-derived mesenchymal stromal cells. J Cardiovasc Pharmacol Therapeutics 2013; 18: 786. 23 Kim YS, Ahn Y, Kwon JS, Cho YK, Jeong MH, Cho JG et al. Priming of mesenchymal stem cells with oxytocin enhances the cardiac repair in ischemia/reperfusion injury.Quavonlimab Cells Tissues Organs 2012; 195: 42842.Resmetirom 24 Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O’Garra A, Murphy KM.PMID:24360118 Development of TH1 CD4 T cells via IL-12 made by Listeriainduced macrophages. Science 1993; 260: 54749. 25 de Jager SC, Bot I, Kraaijeveld AO, Korporaal SJ, Bot M, van Santbrink PJ et al. Leukocyte-specific CCL3 deficiency inhibits atherosclerotic lesion development by affecting neutrophil accumulation. Arteriosclerosis Thrombosis Vasc Biol 2013; 33: e75 83. 26 Hehlgans T, Pfeffer K. The intriguing biology in the tumour necrosis factor/ tumour necrosis aspect receptor superfamily: players, guidelines plus the games. Immunology 2005; 115: 10. 27 Kim CH. Chemokine-chemokine receptor network in immune cell trafficking. Curr Drug Targets Immune Endocr Metabol Disord 2004; four: 34361.This operate is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs three.0 Unported License. To view a copy of this license, check out http:// creativecommons.org/licenses/by-nc-nd/3.0/Experimental Molecular Medicine
Functional impairments and disability are widespread among persons with knee osteoarthritis (OA)1,two. Inside the elderly, knee OA contributes to as a lot chronic disability as cardiovascular disease3. There isn’t any disease-modifying therapy for OA; practice guidelines suggest strength training as an effective intervention to decrease symptom.

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