Product Name :
BGT226
Description:
BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.
CAS:
915020-55-2
Molecular Weight:
534.53
Formula:
C28H25F3N6O2
Chemical Name:
8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1H,2H,3H-imidazo[4,5-c]quinolin-2-one
Smiles :
CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1C=NC(=CC=1)OC)C1C=C(C(=CC=1)N1CCNCC1)C(F)(F)F
InChiKey:
BMMXYEBLEBULND-UHFFFAOYSA-N
InChi :
InChI=1S/C28H25F3N6O2/c1-35-24-16-33-22-6-3-17(18-4-8-25(39-2)34-15-18)13-20(22)26(24)37(27(35)38)19-5-7-23(21(14-19)28(29,30)31)36-11-9-32-10-12-36/h3-8,13-16,32H,9-12H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.|Product information|CAS Number: 915020-55-2|Molecular Weight: 534.53|Formula: C28H25F3N6O2|Chemical Name: 8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1H,2H,3H-imidazo[4,5-c]quinolin-2-one|Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1C=NC(=CC=1)OC)C1C=C(C(=CC=1)N1CCNCC1)C(F)(F)F|InChiKey: BMMXYEBLEBULND-UHFFFAOYSA-N|InChi: InChI=1S/C28H25F3N6O2/c1-35-24-16-33-22-6-3-17(18-4-8-25(39-2)34-15-18)13-20(22)26(24)37(27(35)38)19-5-7-23(21(14-19)28(29,30)31)36-11-9-32-10-12-36/h3-8,13-16,32H,9-12H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{GDNF Protein, Human} site|{GDNF Protein, Human} Technical Information|{GDNF Protein, Human} In Vivo|{GDNF Protein, Human} manufacturer|{GDNF Protein, Human} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Naptumomab} web|{Naptumomab} Biological Activity|{Naptumomab} Data Sheet|{Naptumomab} supplier|{Naptumomab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35954127 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BGT226 shows significant growth inhibition or signal blockage profiles compared with LY294002 and Rapamycin. BGT226 (10-10000 nM) inhibits FaDu and OECM1 cells growth with IC50s of 23.1±7.4 and 12.5±5.1 nM, respectively. The expression levels of p-mTOR Ser2481 are decreased in BGT226-treated cell lines (200 nM; 24 hours) and both p-AKT Ser473 and p-mTOR Ser2448 are also decreased in BGT226-treated cell lines.|In Vivo:|BGT226 (2.5 and 5 mg/kg; oral administration for 21 days in male athymic mice) causes 34.7% and 76.1% reduction of the tumor growth on day 21 compared with control.|Products are for research use only. Not for human use.|
