Product Name :
CXCR7 modulator 2
Description:
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.
CAS:
2227426-37-9
Molecular Weight:
522.68
Formula:
C29H42N6O3
Chemical Name:
(3S)-3-(4-{7-ethylimidazo[1,2-a]pyridin-8-yl}-1,4-diazepan-1-yl)-3-{1-[(1R,2S,4S)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]piperidin-4-yl}propanamide
Smiles :
CCC1C=CN2C=CN=C2C=1N1CCCN(CC1)[C@@H](CC(N)=O)C1CCN(CC1)C(=O)[C@H]1C[C@@H]2CC[C@H]1O2
InChiKey:
CERHKHQEGFSIHF-OJJQZRKESA-N
InChi :
InChI=1S/C29H42N6O3/c1-2-20-6-12-34-15-9-31-28(34)27(20)33-11-3-10-32(16-17-33)24(19-26(30)36)21-7-13-35(14-8-21)29(37)23-18-22-4-5-25(23)38-22/h6,9,12,15,21-25H,2-5,7-8,10-11,13-14,16-19H2,1H3,(H2,30,36)/t22-,23-,24-,25+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM.|Product information|CAS Number: 2227426-37-9|Molecular Weight: 522.68|Formula: C29H42N6O3|Chemical Name: (3S)-3-(4-{7-ethylimidazo[1,2-a]pyridin-8-yl}-1,4-diazepan-1-yl)-3-{1-[(1R,2S,4S)-7-oxabicyclo[2.2.1]heptane-2-carbonyl]piperidin-4-yl}propanamide|Smiles: CCC1C=CN2C=CN=C2C=1N1CCCN(CC1)[C@@H](CC(N)=O)C1CCN(CC1)C(=O)[C@H]1C[C@@H]2CC[C@H]1O2|InChiKey: CERHKHQEGFSIHF-OJJQZRKESA-N|InChi: InChI=1S/C29H42N6O3/c1-2-20-6-12-34-15-9-31-28(34)27(20)33-11-3-10-32(16-17-33)24(19-26(30)36)21-7-13-35(14-8-21)29(37)23-18-22-4-5-25(23)38-22/h6,9,12,15,21-25H,2-5,7-8,10-11,13-14,16-19H2,1H3,(H2,30,36)/t22-,23-,24-,25+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (478.{{Rapamycin} MedChemExpress|{Rapamycin} Anti-infection|{Rapamycin} Purity & Documentation|{Rapamycin} Purity|{Rapamycin} manufacturer|{Rapamycin} Autophagy} 30 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CXCR7 modulator 2 (compound 18) demonstrates potent CXCR7-binding affinity (Ki=13 nM) and β-arrestin activity (EC50=11 nM).{{Nimesulide} MedChemExpress|{Nimesulide} Immunology/Inflammation|{Nimesulide} Purity & Documentation|{Nimesulide} Description|{Nimesulide} custom synthesis|{Nimesulide} Epigenetics} CXCR7 modulator 2 also exhibits improved selectivity in the GPCR panel and an improved therapeutic index in the hERG patch-clamp assay in comparison with 11c.PMID:23937941 CXCR7 modulator 2 exhibits moderate to high in vitro turn over in both NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells), shows poor passive absorptive permeability in the MDCK II-permeability assay, and has good aqueous solubility. CXCR7 modulator 2 is rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL, which occurrs at 0.25 h (Tmax). The corresponding mean area under the plasma-concentration-versus-time profile (AUC) is 740 ng/mL/h.|In Vivo:|The administration of isoproterenol for 9 days leads to the development of cardiac fibrosis, as attested by the approximately 4-fold increase in collagen deposition relative to that in the control, which is detected by picrosirius-red staining. Treatment with CXCR7 modulator 2 results in a statistically significant reduction in cardiac fibrosis, thereby demonstrating the protective role of CXCR7 modulation with CXCR7 modulator 2 in an isoproterenol-induced cardiac injury.|Products are for research use only. Not for human use.|
