Product Name :
CD73-IN-3
Description:
CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research.
CAS:
2375815-63-5
Molecular Weight:
286.33
Formula:
C15H18N4O2
Chemical Name:
5-{6-methyl-5-[(1S,2R)-2-(propan-2-yl)cyclopropyl]pyridazin-3-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione
Smiles :
CC1=NN=C(C=C1[C@H]1C[C@@H]1C(C)C)C1=CNC(=O)NC1=O
InChiKey:
WHRUIISQCORGKK-KOLCDFICSA-N
InChi :
InChI=1S/C15H18N4O2/c1-7(2)9-4-11(9)10-5-13(19-18-8(10)3)12-6-16-15(21)17-14(12)20/h5-7,9,11H,4H2,1-3H3,(H2,16,17,20,21)/t9-,11+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research.|Product information|CAS Number: 2375815-63-5|Molecular Weight: 286.33|Formula: C15H18N4O2|Chemical Name: 5-{6-methyl-5-[(1S,2R)-2-(propan-2-yl)cyclopropyl]pyridazin-3-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione|Smiles: CC1=NN=C(C=C1[C@H]1C[C@@H]1C(C)C)C1=CNC(=O)NC1=O|InChiKey: WHRUIISQCORGKK-KOLCDFICSA-N|InChi: InChI=1S/C15H18N4O2/c1-7(2)9-4-11(9)10-5-13(19-18-8(10)3)12-6-16-15(21)17-14(12)20/h5-7,9,11H,4H2,1-3H3,(H2,16,17,20,21)/t9-,11+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (436.{{Parsaclisib} site|{Parsaclisib} PI3K|{Parsaclisib} Purity & Documentation|{Parsaclisib} Description|{Parsaclisib} supplier|{Parsaclisib} Cancer} 56 mM; ultrasonic and warming and heat to 60°C).{{Ustekinumab} web|{Ustekinumab} Immunology/Inflammation|{Ustekinumab} Technical Information|{Ustekinumab} Description|{Ustekinumab} custom synthesis|{Ustekinumab} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:34645436 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CD73-IN-3 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively. In Calu6 human cell assay against CD73, the IC50 for CD73-IN-3 against CD73 is 0.0073 uM.|Products are for research use only. Not for human use.|
