Product Name :
Ischemin, CBP Bromodomain Inhibitor
Description:
Ischemin is a potent, selective and cell permeable CBP bromodomain inhibitor. It inhibits the acetyl-lysine binding activity of the bromodomain of CBP. It alters post-translational modifications on p53 and histones, inhibits p53 interaction with CBP and transcriptional activity in cells, and prevents Doxorubicin-induced apoptosis in ischemic cardiomyocytes. Ischemin is a good chemical probe to modulate acetylation-mediated interactions in gene transcription and a new approach to therapeutic interventions of human disorders such as myocardial ischemia
CAS:
1357059-00-7
Molecular Weight:
357.36
Formula:
C15H16N3NaO4S
Chemical Name:
sodium (E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonate
Smiles :
[Na+].CC1C=C(/N=N/C2C=C(C(C)=CC=2C)S([O-])(=O)=O)C(N)=CC=1O
InChiKey:
ZTDQQIATQGCZBV-ZAGWXBKKSA-M
InChi :
InChI=1S/C15H17N3O4S.Na/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16;/h4-7,19H,16H2,1-3H3,(H,20,21,22);/q;+1/p-1/b18-17+;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ischemin is a potent, selective and cell permeable CBP bromodomain inhibitor. It inhibits the acetyl-lysine binding activity of the bromodomain of CBP. It alters post-translational modifications on p53 and histones, inhibits p53 interaction with CBP and transcriptional activity in cells, and prevents Doxorubicin-induced apoptosis in ischemic cardiomyocytes. Ischemin is a good chemical probe to modulate acetylation-mediated interactions in gene transcription and a new approach to therapeutic interventions of human disorders such as myocardial ischemia|Product information|CAS Number: 1357059-00-7|Molecular Weight: 357.36|Formula: C15H16N3NaO4S|Chemical Name: sodium (E)-5-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-2,4-dimethylbenzenesulfonate|Smiles: [Na+].CC1C=C(/N=N/C2C=C(C(C)=CC=2C)S([O-])(=O)=O)C(N)=CC=1O|InChiKey: ZTDQQIATQGCZBV-ZAGWXBKKSA-M|InChi: InChI=1S/C15H17N3O4S.Na/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16;/h4-7,19H,16H2,1-3H3,(H,20,21,22);/q;+1/p-1/b18-17+;|Technical Data|Appearance: Solid Power.{{Feladilimab} web|{Feladilimab} Immunology/Inflammation|{Feladilimab} Technical Information|{Feladilimab} In Vivo|{Feladilimab} manufacturer} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rebamipide} medchemexpress|{Rebamipide} COX|{Rebamipide} Protocol|{Rebamipide} References|{Rebamipide} custom synthesis|{Rebamipide} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:32472497 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Ischemin was used at 10-50 µM final concentration in various in vitro assays.|References:|Borah JC, et al. A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. (2011) Chem Biol. 18(4):531-41.Products are for research use only. Not for human use.|Documents||
