Product Name :
Osthole
Description:
Osthole (Osthol) is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity. Osthole also suppresses the secretion of HBV in cells.
CAS:
484-12-8
Molecular Weight:
244.29
Formula:
C15H16O3
Chemical Name:
7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
Smiles :
CC(C)=CCC1=C2OC(=O)C=CC2=CC=C1OC
InChiKey:
MBRLOUHOWLUMFF-UHFFFAOYSA-N
InChi :
InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Stenoparib} site|{Stenoparib} Inhibitor|{Stenoparib} Activator|{Stenoparib} Purity & Documentation|{Stenoparib} Formula|{Stenoparib} supplier}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Osthole (Osthol) is a natural antihistamine alternative.{{β-Endorphin, human} web|{β-Endorphin, human} Agonist|{β-Endorphin, human} Immunology/Inflammation|{β-Endorphin, human} Purity & Documentation|{β-Endorphin, human} In Vivo|{β-Endorphin, human} custom synthesis} Osthole may be a potential inhibitor of histamine H1 receptor activity.PMID:24101108 Osthole also suppresses the secretion of HBV in cells.|Product information|CAS Number: 484-12-8|Molecular Weight: 244.29|Formula: C15H16O3|Synonym:|Osthol|Ostole|Ostol|Chemical Name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one|Smiles: CC(C)=CCC1=C2OC(=O)C=CC2=CC=C1OC|InChiKey: MBRLOUHOWLUMFF-UHFFFAOYSA-N|InChi: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 49 mg/mL(200.58 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg.|In Vivo:|LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.).|References:|Huang RL, et al. Hepatology, 1996, 24(3), 508-515.Kuo PL, et al. J Pharmacol Exp Ther, 2005, 314(3), 1290-1299.Ko FN, et al. Thromb Haemost, 1989, 62(3), 996-999.Products are for research use only. Not for human use.|
