Product Name :
ZM223
Description:
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.
CAS:
2031177-48-5
Molecular Weight:
502.53
Formula:
C23H17F3N4O2S2
Chemical Name:
N-[6-[[2-(4-aminophenyl)sulfanylacetyl]amino]-1, 3-benzothiazol-2-yl]-4-(trifluoromethyl)benzamide
Smiles :
NC1C=CC(=CC=1)SCC(=O)NC1=CC=C2N=C(NC(=O)C3C=CC(=CC=3)C(F)(F)F)SC2=C1
InChiKey:
XPPKZMFJCSEUSX-UHFFFAOYSA-N
InChi :
InChI=1S/C23H17F3N4O2S2/c24-23(25,26)14-3-1-13(2-4-14)21(32)30-22-29-18-10-7-16(11-19(18)34-22)28-20(31)12-33-17-8-5-15(27)6-9-17/h1-11H,12,27H2,(H,28,31)(H,29,30,32)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Bictegravir} site|{Bictegravir} HIV|{Bictegravir} Purity & Documentation|{Bictegravir} In stock|{Bictegravir} manufacturer|{Bictegravir} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ZM223 is a potent non-covalent NEDD8 activating enzyme (NAE) inhibitor, orally active.|Product information|CAS Number: 2031177-48-5|Molecular Weight: 502.53|Formula: C23H17F3N4O2S2|Chemical Name: N-[6-[[2-(4-aminophenyl)sulfanylacetyl]amino]-1, 3-benzothiazol-2-yl]-4-(trifluoromethyl)benzamide|Smiles: NC1C=CC(=CC=1)SCC(=O)NC1=CC=C2N=C(NC(=O)C3C=CC(=CC=3)C(F)(F)F)SC2=C1|InChiKey: XPPKZMFJCSEUSX-UHFFFAOYSA-N|InChi: InChI=1S/C23H17F3N4O2S2/c24-23(25,26)14-3-1-13(2-4-14)21(32)30-22-29-18-10-7-16(11-19(18)34-22)28-20(31)12-33-17-8-5-15(27)6-9-17/h1-11H,12,27H2,(H,28,31)(H,29,30,32)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (165.82 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Phycocyanobilin} MedChemExpress|{Phycocyanobilin} Immunology/Inflammation|{Phycocyanobilin} Activator|{Phycocyanobilin} Technical Information|{Phycocyanobilin} References|{Phycocyanobilin} custom synthesis} |Shelf Life: ≥12 months if stored properly.PMID:25558565 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively. ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.|Products are for research use only. Not for human use.|
