Product Name :
ALK-IN-5
Description:
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM.
CAS:
2351929-66-1
Molecular Weight:
464.49
Formula:
C24H25FN6O3
Chemical Name:
(2S)-4-{6-[(1S)-1-(5-fluoropyridin-2-yl)ethoxy]-1-(5-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2-methylmorpholine
Smiles :
CC1=CC(=NN1)N1C=C(C(=O)N2C[C@H](C)OCC2)C2=CC=C(N=C12)O[C@@H](C)C1=CC=C(F)C=N1
InChiKey:
UTDAGOYVDYQGFI-HOTGVXAUSA-N
InChi :
InChI=1S/C24H25FN6O3/c1-14-10-21(29-28-14)31-13-19(24(32)30-8-9-33-15(2)12-30)18-5-7-22(27-23(18)31)34-16(3)20-6-4-17(25)11-26-20/h4-7,10-11,13,15-16H,8-9,12H2,1-3H3,(H,28,29)/t15-,16-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.{{Laccaic acid A} MedChemExpress|{Laccaic acid A} Deubiquitinase|{Laccaic acid A} Technical Information|{Laccaic acid A} References|{Laccaic acid A} custom synthesis|{Laccaic acid A} Epigenetic Reader Domain} 9 nM.|Product information|CAS Number: 2351929-66-1|Molecular Weight: 464.49|Formula: C24H25FN6O3|Chemical Name: (2S)-4-{6-[(1S)-1-(5-fluoropyridin-2-yl)ethoxy]-1-(5-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2-methylmorpholine|Smiles: CC1=CC(=NN1)N1C=C(C(=O)N2C[C@H](C)OCC2)C2=CC=C(N=C12)O[C@@H](C)C1=CC=C(F)C=N1|InChiKey: UTDAGOYVDYQGFI-HOTGVXAUSA-N|InChi: InChI=1S/C24H25FN6O3/c1-14-10-21(29-28-14)31-13-19(24(32)30-8-9-33-15(2)12-30)18-5-7-22(27-23(18)31)34-16(3)20-6-4-17(25)11-26-20/h4-7,10-11,13,15-16H,8-9,12H2,1-3H3,(H,28,29)/t15-,16-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Eltrombopag} medchemexpress|{Eltrombopag} Apoptosis|{Eltrombopag} Protocol|{Eltrombopag} In Vitro|{Eltrombopag} manufacturer|{Eltrombopag} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:24576999 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ALK-IN-5 potently inhibits ALK with cellular IC50 of 27 nM.|Products are for research use only. Not for human use.|
