Product Name :
GNE-0439
Description:
GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders.
CAS:
1241902-40-8
Molecular Weight:
345.48
Formula:
C21H31NO3
Chemical Name:
(2S)-3-methyl-2-{[4-(4-propylcyclohexyl)phenyl]formamido}butanoic acid
Smiles :
CC(C)[C@H](NC(=O)C1=CC=C(C=C1)C1CCC(CCC)CC1)C(O)=O
InChiKey:
SKMKUWKJBZSEJH-RJYAGPCLSA-N
InChi :
InChI=1S/C21H31NO3/c1-4-5-15-6-8-16(9-7-15)17-10-12-18(13-11-17)20(23)22-19(14(2)3)21(24)25/h10-16,19H,4-9H2,1-3H3,(H,22,23)(H,24,25)/t15?,16?,19-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders.|Product information|CAS Number: 1241902-40-8|Molecular Weight: 345.48|Formula: C21H31NO3|Chemical Name: (2S)-3-methyl-2-{[4-(4-propylcyclohexyl)phenyl]formamido}butanoic acid|Smiles: CC(C)[C@H](NC(=O)C1=CC=C(C=C1)C1CCC(CCC)CC1)C(O)=O|InChiKey: SKMKUWKJBZSEJH-RJYAGPCLSA-N|InChi: InChI=1S/C21H31NO3/c1-4-5-15-6-8-16(9-7-15)17-10-12-18(13-11-17)20(23)22-19(14(2)3)21(24)25/h10-16,19H,4-9H2,1-3H3,(H,22,23)(H,24,25)/t15?,16?,19-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Alogliptin} medchemexpress|{Alogliptin} Apoptosis|{Alogliptin} Purity & Documentation|{Alogliptin} Description|{Alogliptin} custom synthesis|{Alogliptin} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Hapten C} MedChemExpress|{Hapten C} {Biochemical Assay Reagents}|{Hapten C} NF-κB|{Hapten C} Biological Activity|{Hapten C} In Vivo|{Hapten C} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33292028 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
