Product Name :
Nitidine chloride
Description:
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway.
CAS:
13063-04-2
Molecular Weight:
383.82
Formula:
C21H18ClNO4
Chemical Name:
16, 17-dimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.8.0.0, .0, .0, ]henicosa-1, 3, 8, 10, 12, 14, 16, 18, 20-nonaen-21-ium chloride
Smiles :
[Cl-].C[N+]1=CC2=CC(OC)=C(C=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC
InChiKey:
QLDAACVSUMUMOR-UHFFFAOYSA-M
InChi :
InChI=1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Gossypol} medchemexpress|{Gossypol} Bcl-2 Family|{Gossypol} Biological Activity|{Gossypol} In stock|{Gossypol} supplier|{Gossypol} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Rilotumumab} web|{Rilotumumab} Protein Tyrosine Kinase/RTK|{Rilotumumab} Technical Information|{Rilotumumab} Description|{Rilotumumab} supplier|{Rilotumumab} Cancer}
Additional information:
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway.PMID:32809354 Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway.|Product information|CAS Number: 13063-04-2|Molecular Weight: 383.82|Formula: C21H18ClNO4|Chemical Name: 16, 17-dimethoxy-21-methyl-5, 7-dioxa-21-azapentacyclo[11.8.0.0, .0, .0, ]henicosa-1, 3, 8, 10, 12, 14, 16, 18, 20-nonaen-21-ium chloride|Smiles: [Cl-].C[N+]1=CC2=CC(OC)=C(C=C2C2=CC=C3C=C4OCOC4=CC3=C12)OC|InChiKey: QLDAACVSUMUMOR-UHFFFAOYSA-M|InChi: InChI=1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 2 mg/mL (5.21 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Chen J, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87.Products are for research use only. Not for human use.|
