Product Name :
PF-562271
Sequence:
Purity:
≥95% (HPLC)
Molecular Weight:
507.5
Solubility :
Soluble in DMSO (101mg/ml) or ethanol (1mg/ml).
Appearance:
White powder.
Use/Stability :
As indicated on product label or CoA when stored as recommended.
Description:
FAK and Pyk2 inhibitor with robust antitumor activity PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC50 of 1.5 and 14 nmol/l, respectively (PMID 18339875). In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC50 of 5 nmol/l. PF-562,271 was evaluated against multiple kinases and displays >100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93 ng/ml) using injections.Focal Adhesion Kinase (FAK) is a protein coded by the PTK2 gene that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis.
CAS :
717907-75-0
Solubility:
Soluble in DMSO (101mg/ml) or ethanol (1mg/ml).
Formula:
C21H20F3N7O3S
Additional Information :
| Alternative Name N-methyl-n-[3-[[[2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Appearance White powder.{{273404-37-8} web|{273404-37-8} Protocol|{273404-37-8} Data Sheet|{273404-37-8} custom synthesis} | CAS 717907-75-0 | Couple Target FAK, Pyk | Couple Type Inhibitor | Formula C21H20F3N7O3S | Identity Determined by EM-MS, NMR | MW 507.{{347174-05-4} web|{347174-05-4} Technical Information|{347174-05-4} In Vitro|{347174-05-4} manufacturer} 5 | Purity ≥95% (HPLC) | Solubility Soluble in DMSO (101mg/ml) or ethanol (1mg/ml).PMID:27809436 | Unit of Measure (UM) mg
