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UNC45a monoclonal antibody (AbS1)
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GC UNC45 (general cell UNC45/unc45a) is an Hsp90 co-chaperone that has been shown to play a critical role in the chaperoning of myosin proteins as well as the progesterone receptor (PR). There are two known vertebrate isoforms of UNC45 that are functional orthologs of the C. elegans unc-45, an important protein in the development of organized body wall muscles. The vertebrate general cell form (GC UNC45/unc45a) is ubiquitously expressed, while the striated muscle-specific isoform (SM UNC45/unc45b) is found in cardiac and skeletal muscle. In vitro, GC UNC45 preferentially binds the Hsp90 beta isoform, and is specifically required for proper cellular distribution of Hsp90β but not Hsp90α. Western blot analysis of UNC45: Lane 1: MW marker, Lane 2: HeLa, Lane 3: 3T3, Lane 4: PC-12. Western blot analysis of UNC45: Lane 1: MW marker, Lane 2: HeLa, Lane 3: 3T3, Lane 4: PC-12.
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| Application WB | Application Notes Detects a band of ~98kDa by Western blot.63700-19-6 supplier | Clone AbS1 | Formulation Liquid.841205-47-8 Purity & Documentation In PBS containing 50% glycerol and 0.PMID:30335310 09% sodium azide. | Host Mouse | Immunogen Recombinant human UNC45. | Isotype IgG2b | Recommendation Dilutions/Conditions Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from mouse ascites. | Species Reactivity Human, Mouse, Rat | UniProt ID Q9H3U1 | Unit of Measure (UM) µg
