Proanthocyanidins

Additional information:
Proanthocyanidins are a class of polyphenolic that are widely distributed in higher plants, consisted of an electrophilic flavanyl unit. Proanthocyanidins can be used as antioxidant and anti-cancers agent. Proanthocyanidins also exhibit anti-inflammatory, cardioprotective, antibacterial and antifungal properties, which can be used in the treatment of chronic venous insufficiency, capillary fragility, sunburn and retinopathy..|Product information|CAS Number: 20347-71-1|Molecular Weight: 594.52|Formula: C30H26O13|Chemical Name: 2-(3,4-dihydroxyphenyl)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-3-yl]oxy-3,4-dihydro-2H-1-benzopyran-3,4,5,7-tetrol|Smiles: OC1C=C(O)C=C2OC(C(CC=12)OC1(OC2=CC(O)=CC(O)=C2C(O)C1O)C1C=C(O)C(O)=CC=1)C1C=C(O)C(O)=CC=1|InChiKey: HGVVOUNEGQIPMS-UHFFFAOYSA-N|InChi: InChI=1S/C30H26O13/c31-14-7-19(35)16-11-25(28(41-23(16)9-14)12-1-3-17(33)20(36)5-12)43-30(13-2-4-18(34)21(37)6-13)29(40)27(39)26-22(38)8-15(32)10-24(26)42-30/h1-10,25,27-29,31-40H,11H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (168.Schisandrin Biological Activity 20 mM; Need ultrasonic). H2O : 5 mg/mL (8.41 mM; ultrasonic and adjust pH to 11 with Na2CO3).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Gemfibrozil supplier |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Proanthocyanidins are present in plants as complex mixtures of polymers.PMID:33331243 Predominant food sources are red wine, tea, chocolate and fruits like grapes, apples, pears, and cranberries. The most interesting antibacterial activity of Proanthocyanidins is related to their presence in cranberries (Vaccinium macrocarpon Ait.). A number of clinical trials have demonstrated the effectiveness of cranberry consumption in preventing urinary tract infections (UTIs). Although UTIs can be caused by many microorganisms, more than 85% are caused by Escherichia coli. The presence of P-fimbriae on E. coli, which are proteinaceous fibers on the bacterial cell wall, has been clearly established as a virulence factor, since they are responsible by producing adhesions for adherence to uroepithelial cells. Recently, it is demonstrated that cranberry Proanthocyanidins might inhibit P-fimbriated E. coli from adhering to uroepithelial cells. The antiadhesion activity of cranberry juice appears to be related to the presence of Proanthocyanidins with at least one A-type linkage.|In Vivo:|The effects of cacao liquor Proanthocyanidins on 2- amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced mutagenesis in vivo carcinogenesis in female Sprague-Dawley rats are investigated. In the Ames assay, Proanthocyanidins shows strong antimutagenic effects when assayed in the presence of S-9 mixture. They also inhibit significantly rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis.|Products are for research use only. Not for human use.|