Product Name :
LY2940094
Description:
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models.
CAS:
1307245-86-8
Molecular Weight:
480.96
Formula:
C22H23ClF2N4O2S
Chemical Name:
2-[4-(2′-chloro-4′,4′-difluoro-4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-ylmethyl)-3-methyl-1H-pyrazol-1-yl]pyridin-3-ylmethanol
Smiles :
CC1=NN(C=C1CN1CCC2(CC1)OCC(F)(F)C1C=C(Cl)SC2=1)C1=NC=CC=C1CO
InChiKey:
NKQHBJNRBKHUQR-UHFFFAOYSA-N
InChi :
InChI=1S/C22H23ClF2N4O2S/c1-14-16(11-29(27-14)20-15(12-30)3-2-6-26-20)10-28-7-4-21(5-8-28)19-17(9-18(23)32-19)22(24,25)13-31-21/h2-3,6,9,11,30H,4-5,7-8,10,12-13H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Iloprost Metabolic Enzyme/Protease
Shelf Life:
≥12 months if stored properly.WS6 Protocol
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models.|Product information|CAS Number: 1307245-86-8|Molecular Weight: 480.96|Formula: C22H23ClF2N4O2S|Chemical Name: 2-[4-(2′-chloro-4′,4′-difluoro-4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-ylmethyl)-3-methyl-1H-pyrazol-1-yl]pyridin-3-ylmethanol|Smiles: CC1=NN(C=C1CN1CCC2(CC1)OCC(F)(F)C1C=C(Cl)SC2=1)C1=NC=CC=C1CO|InChiKey: NKQHBJNRBKHUQR-UHFFFAOYSA-N|InChi: InChI=1S/C22H23ClF2N4O2S/c1-14-16(11-29(27-14)20-15(12-30)3-2-6-26-20)10-28-7-4-21(5-8-28)19-17(9-18(23)32-19)22(24,25)13-31-21/h2-3,6,9,11,30H,4-5,7-8,10,12-13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 41.PMID:32875978 67 mg/mL (86.64 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|LY2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity.|Products are for research use only. Not for human use.|
