Product Name :
Ki16198
Description:
Ki16198 is a potent and orally active LPA receptor antagonist, the methyl ester of Ki16425 (HY-13285). Ki16198 inhibits LPA1 and LPA3-induced inositol phosphate production with Ki values of 0.34 μM and 0.93 μM, respectively. Ki16198 is effective for pancreatic cancer tumorigenesis and metastasis in vivo.
CAS:
355025-13-7
Molecular Weight:
488.98
Formula:
C24H25ClN2O5S
Chemical Name:
methyl 3-[(4-[4-([1-(2-chlorophenyl)ethoxy]carbonylamino)-3-methyl-1,2-oxazol-5-yl]phenylmethyl)sulfanyl]propanoate
Smiles :
CC1=NOC(=C1NC(=O)OC(C)C1=CC=CC=C1Cl)C1C=CC(CSCCC(=O)OC)=CC=1
InChiKey:
HHVJBROTJWPHHX-UHFFFAOYSA-N
InChi :
InChI=1S/C24H25ClN2O5S/c1-15-22(26-24(29)31-16(2)19-6-4-5-7-20(19)25)23(32-27-15)18-10-8-17(9-11-18)14-33-13-12-21(28)30-3/h4-11,16H,12-14H2,1-3H3,(H,26,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Gemifloxacin Antibiotic
Shelf Life:
≥12 months if stored properly.Bromhexine site
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ki16198 is a potent and orally active LPA receptor antagonist, the methyl ester of Ki16425 (HY-13285). Ki16198 inhibits LPA1 and LPA3-induced inositol phosphate production with Ki values of 0.34 μM and 0.93 μM, respectively. Ki16198 is effective for pancreatic cancer tumorigenesis and metastasis in vivo.|Product information|CAS Number: 355025-13-7|Molecular Weight: 488.98|Formula: C24H25ClN2O5S|Chemical Name: methyl 3-[(4-[4-([1-(2-chlorophenyl)ethoxy]carbonylamino)-3-methyl-1,2-oxazol-5-yl]phenylmethyl)sulfanyl]propanoate|Smiles: CC1=NOC(=C1NC(=O)OC(C)C1=CC=CC=C1Cl)C1C=CC(CSCCC(=O)OC)=CC=1|InChiKey: HHVJBROTJWPHHX-UHFFFAOYSA-N|InChi: InChI=1S/C24H25ClN2O5S/c1-15-22(26-24(29)31-16(2)19-6-4-5-7-20(19)25)23(32-27-15)18-10-8-17(9-11-18)14-33-13-12-21(28)30-3/h4-11,16H,12-14H2,1-3H3,(H,26,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (204.PMID:32541443 51 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ki16198 (0-10 μM; 48 hours) is effective to inhibit migration and invasion responses to LPA with a potency similar to that of Ki16425. The inhibitory effects Ki16198 on the invasion response to LPA, but not to EGF in several pancreatic cancer cell lines, including Panc-1,CFPAC-1, and BxPC-3 cells. Ki16198 (10 μM; 48 hours) signifivcantly decreases expression of proMMP-9 protein and mRNA expression in YAPC-PD cells.|In Vivo:|Ki16198 (oral administaion; 1 mg in 500 ul; 28 days) significantly decreases the degree of metastasis activity in Ki16198-treated mice. Similiar to liver, metastasis to lung and brain in mice is also observed.|Products are for research use only. Not for human use.|
