Product Name :
KL001, Cryptochrome Activator
Description:
KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.
CAS:
309928-48-1
Molecular Weight:
398.48
Formula:
C21H22N2O4S
Chemical Name:
N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-[(furan-2-yl)methyl]methanesulfonamide
Smiles :
CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1
InChiKey:
OQAFDLPAPSSOHY-UHFFFAOYSA-N
InChi :
InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KL001 is a novel and specific small molecule activator of cryptochrome (CRY) identified from an unbiased cell-based circadian screen (in human osteosarcoma U2OS cell line harboring a Bmal1-dLuc luciferase reporter).{{Bisacodyl} medchemexpress|{Bisacodyl} Opioid Receptor|{Bisacodyl} Biological Activity|{Bisacodyl} References|{Bisacodyl} manufacturer|{Bisacodyl} Autophagy} KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period.{{Gramicidin S} MedChemExpress|{Gramicidin S} Bacterial|{Gramicidin S} Activator|{Gramicidin S} Technical Information|{Gramicidin S} In stock|{Gramicidin S} supplier} In addition, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes.PMID:24406011 Therefore, KL001 serves as a useful tool to study the regulation of CRY-dependent physiology and may help development of clock-based therapeutics for treating diabetes.|Product information|CAS Number: 309928-48-1|Molecular Weight: 398.48|Formula: C21H22N2O4S|Chemical Name: N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-[(furan-2-yl)methyl]methanesulfonamide|Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1|InChiKey: OQAFDLPAPSSOHY-UHFFFAOYSA-N|InChi: InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|KL001 was used at 10-50 µM in vitro and in cellular assays.|References:|Hirota T, et al. Identification of Small Molecule Activators of Cryptochrome. (2012) Science 337(6098):1094-7.Products are for research use only. Not for human use.|
