Product Name :
NIK SMI1
Description:
NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.
CAS:
1660114-31-7
Molecular Weight:
365.38
Formula:
C20H19N3O4
Chemical Name:
(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide
Smiles :
COC1=CC(=NC(=C1)C1=CC(=CC=C1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O
InChiKey:
LQSHXYHWYGKAMX-FQEVSTJZSA-N
InChi :
InChI=1S/C20H19N3O4/c1-23-9-8-20(26,19(23)25)7-6-13-4-3-5-14(10-13)16-11-15(27-2)12-17(22-16)18(21)24/h3-5,10-12,26H,8-9H2,1-2H3,(H2,21,24)/t20-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.|Product information|CAS Number: 1660114-31-7|Molecular Weight: 365.38|Formula: C20H19N3O4|Chemical Name: (R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide|Smiles: COC1=CC(=NC(=C1)C1=CC(=CC=C1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O|InChiKey: LQSHXYHWYGKAMX-FQEVSTJZSA-N|InChi: InChI=1S/C20H19N3O4/c1-23-9-8-20(26,19(23)25)7-6-13-4-3-5-14(10-13)16-11-15(27-2)12-17(22-16)18(21)24/h3-5,10-12,26H,8-9H2,1-2H3,(H2,21,24)/t20-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 73 mg/mL (199.{{DBCO-Biotin} site|{DBCO-Biotin} PROTAC Linkers|{DBCO-Biotin} TGF-beta/Smad|{DBCO-Biotin} Biological Activity|{DBCO-Biotin} Purity|{DBCO-Biotin} supplier} 79 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{NAD+/NADH Assay Kit} medchemexpress|{NAD+/NADH Assay Kit} TGF-beta/Smad|{NAD+/NADH Assay Kit} Protocol|{NAD+/NADH Assay Kit} Description|{NAD+/NADH Assay Kit} manufacturer} |Shelf Life: ≥12 months if stored properly.PMID:24732841 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro.|In Vivo:|NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo.|References:|Blaquiere N, et al. J Med Chem. 2018 Aug 9;61(15):6801-6813.Products are for research use only. Not for human use.|
