Product Name :
Mivebresib
Description:
Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.
CAS:
1445993-26-9
Molecular Weight:
459.47
Formula:
C22H19F2N3O4S
Chemical Name:
N-[4-(2,4-difluorophenoxy)-3-{6-methyl-7-oxo-1H,6H,7H-pyrrolo[2,3-c]pyridin-4-yl}phenyl]ethane-1-sulfonamide
Smiles :
CCS(=O)(=O)NC1C=C(C2=CN(C)C(=O)C3NC=CC2=3)C(=CC=1)OC1=CC=C(F)C=C1F
InChiKey:
RDONXGFGWSSFMY-UHFFFAOYSA-N
InChi :
InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.|Product information|CAS Number: 1445993-26-9|Molecular Weight: 459.47|Formula: C22H19F2N3O4S|Chemical Name: N-[4-(2,4-difluorophenoxy)-3-{6-methyl-7-oxo-1H,6H,7H-pyrrolo[2,3-c]pyridin-4-yl}phenyl]ethane-1-sulfonamide|Smiles: CCS(=O)(=O)NC1C=C(C2=CN(C)C(=O)C3NC=CC2=3)C(=CC=1)OC1=CC=C(F)C=C1F|InChiKey: RDONXGFGWSSFMY-UHFFFAOYSA-N|InChi: InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (217.64 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Probucol} medchemexpress|{Probucol} Virus Protease|{Probucol} Purity & Documentation|{Probucol} References|{Probucol} manufacturer|{Probucol} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Fludarabine} site|{Fludarabine} Apoptosis|{Fludarabine} Technical Information|{Fludarabine} In Vivo|{Fludarabine} custom synthesis|{Fludarabine} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23891445 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins.|Products are for research use only. Not for human use.|
