Product Name :
AS1949490
CAS No.:
1203680-76-5
Purity :
99.67%
Shipping:
Room temperature in the continental U.S. Other areas may vary.
Storage :
Powder: -20°C, 3 yearsIn solvent: -80°C, 6 months; -20°C, 1 month
SMILES:
O=C(C1=C(OCC2=CC=C(Cl)C=C2)C=CS1)N[C@H](C3=CC=CC=C3)C
Product Description :
AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively.{{1009298-09-2} site|{1009298-09-2} Biological Activity|{1009298-09-2} Purity|{1009298-09-2} manufacturer} AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes.
Formula:
C20H18ClNO2S
Molecular Weight :
371.88
Synonyms:
Additional Information:
|CAS No. 1203680-76-5 ; |Formula C20H18ClNO2S ; |Molecular Weight 371.{{1359969-24-6} medchemexpress|{1359969-24-6} Protocol|{1359969-24-6} In stock|{1359969-24-6} manufacturer} 88 ; |SMILES O=C(C1=C(OCC2=CC=C(Cl)C=C2)C=CS1)N[C@H](C3=CC=CC=C3)C ; |Target Phosphatase, Akt ; |Product Description AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.PMID:30725946 34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes. ; |Format Solid ; |Color White to off-white ; |Purity 99.67% ; |Shipping Room temperature in the continental U.S. Other areas may vary. ; |Storage Powder: -20°C, 3 yearsIn solvent: -80°C, 6 months; -20°C, 1 month ; |Solubility Overview Soluble in DMSO
