Product Name :
DUPA
Description:
DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells.
CAS:
302941-52-2
Molecular Weight:
320.25
Formula:
C11H16N2O9
Chemical Name:
(2S)-2-({[(1S)-1, 3-dicarboxypropyl]carbamoyl}amino)pentanedioic acid
Smiles :
OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O
InChiKey:
SOAPXKSPJAZNGO-WDSKDSINSA-N
InChi :
InChI=1S/C11H16N2O9/c14-7(15)3-1-5(9(18)19)12-11(22)13-6(10(20)21)2-4-8(16)17/h5-6H,1-4H2,(H,14,15)(H,16,17)(H,18,19)(H,20,21)(H2,12,13,22)/t5-,6-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bisdemethoxycurcumin} web|{Bisdemethoxycurcumin} Apoptosis|{Bisdemethoxycurcumin} Protocol|{Bisdemethoxycurcumin} In stock|{Bisdemethoxycurcumin} supplier|{Bisdemethoxycurcumin} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.{{Loncastuximab tesirine} medchemexpress|{Loncastuximab tesirine} Antibody-Drug Conjugates (ADCs)|{Loncastuximab tesirine} Biological Activity|{Loncastuximab tesirine} Data Sheet|{Loncastuximab tesirine} supplier|{Loncastuximab tesirine} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33050971
Additional information:
DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells.|Product information|CAS Number: 302941-52-2|Molecular Weight: 320.25|Formula: C11H16N2O9|Chemical Name: (2S)-2-({[(1S)-1, 3-dicarboxypropyl]carbamoyl}amino)pentanedioic acid|Smiles: OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O|InChiKey: SOAPXKSPJAZNGO-WDSKDSINSA-N|InChi: InChI=1S/C11H16N2O9/c14-7(15)3-1-5(9(18)19)12-11(22)13-6(10(20)21)2-4-8(16)17/h5-6H,1-4H2,(H,14,15)(H,16,17)(H,18,19)(H,20,21)(H2,12,13,22)/t5-,6-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 300 mg/mL (936.77 mM) H2O : ≥ 150 mg/mL (468.38 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures.|In Vivo:|The DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice.|References:|Peng ZH, et al. Spacer length impacts the efficacy of targeted docetaxel conjugates in prostate-specific membrane antigen expressing prostate cancer. J Drug Target. 2013 Dec;21(10):968-80.Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selective prostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.Products are for research use only. Not for human use.|
