Product Name :
Amifostine thiol dihydrochloride
Description:
Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway.
CAS:
14653-77-1
Molecular Weight:
207.16
Formula:
C5H16Cl2N2S
Chemical Name:
2-[(3-aminopropyl)amino]ethane-1-thiol dihydrochloride
Smiles :
Cl.Cl.NCCCNCCS
InChiKey:
XDRLRDHLCIFZIW-UHFFFAOYSA-N
InChi :
InChI=1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Storage Condition :
Soluble in DMSO
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway.|Product information|CAS Number: 14653-77-1|Molecular Weight: 207.16|Formula: C5H16Cl2N2S|Synonym:|WR-1065 dihydrochloride|Chemical Name: 2-[(3-aminopropyl)amino]ethane-1-thiol dihydrochloride|Smiles: Cl.Cl.NCCCNCCS|InChiKey: XDRLRDHLCIFZIW-UHFFFAOYSA-N|InChi: InChI=1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : ≥ 100 mg/mL (482.72 mM) DMSO : 25 mg/mL (120.68 mM; Need ultrasonic)|Storage Condition: Soluble in DMSO|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The DNA-binding activity is increased in a Amifostine thiol dihydrochloride (Amifostine thiol) concentration-dependent manner.Etesevimab Anti-infection Cells treated with 1 mM Amifostine thiol dihydrochloride for 24 h reveal that all of the p53-induced genes analyzed are transactivated following Amifostine thiol dihydrochloride treatment, in a p53-dependent manner.Selinexor supplier Significantly, treatment with Amifostine thiol dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1, and a 5-fold increase when this reporter gene is driven by NF-κB, when these values are normalized to the level of the cotransfected β-galactosidase gene.PMID:31797337 |In Vivo:|The results show that Amifostine thiol dihydrochloride (Amifostine thiol) attenuates the severity of 6-OHDA-induced catalepsy (PReferences:|Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun;297(3):1067-73.Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496.Products are for research use only. Not for human use.|
