Product Name :
(R)-(+)-Etomoxir Sodium Salt
Description:
Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα.
CAS:
828934-41-4
Molecular Weight:
320.74
Formula:
C15H18ClNaO4
Chemical Name:
(2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid sodium
Smiles :
O=C(O[Na])[C@]1(CO1)CCCCCCOC1C=CC(Cl)=CC=1
InChiKey:
RPACBEVZENYWOL-XFULWGLBSA-M
InChi :
InChI=1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα.|Product information|CAS Number: 828934-41-4|Molecular Weight: 320.74|Formula: C15H18ClNaO4|Synonym:|(+)-Etomoxir sodium salt|Chemical Name: (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylic acid sodium|Smiles: O=C(O[Na])[C@]1(CO1)CCCCCCOC1C=CC(Cl)=CC=1|InChiKey: RPACBEVZENYWOL-XFULWGLBSA-M|InChi: InChI=1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1.Isosorbide mononitrate Technical Information /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (311.Fexinidazole Purity 78 mM; Need ultrasonic) H2O : 5 mg/mL (15.PMID:32755406 59 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Agius L, et al. Differences between human, rat and guinea pig hepatocyte cultures. A comparative study of their rates of beta-oxidation and esterification of palmitate and their sensitivity to R-etomoxir. Biochem Pharmacol. 1991 Oct 9;42(9):1711-5.O’Connor RS, et al. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19;8(1):6289.Products are for research use only. Not for human use.|
