Product Name: QO-58
Description: QO-58 is a Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). QO-58 increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.
CAS NO: 317318-84-6 Product: GW0742
Synonym: QO-58; QO 58;QO58 .
IUPAC Chemical Name: 5-(2,6-dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(trifluoromethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one
In ChiKey: InChI=1S/C18H8Cl2F4N4O/c19-15-9(6-10(21)16(20)26-15)11-7-12(29)28-17(25-11)13(8-4-2-1-3-5-8)14(27-28)18(22,23)24/h1-7,27HAutophagy inhibitors
SMILE Code: O=C1C=C(C2=CC(F)=C(Cl)N=C2Cl)N=C3N1NC(C(F)(F)F)=C3C4=CC=CC=C4
Appearance: Solid powder
Purity: 98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.Web Site click
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: 2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22140368
Chemical Formula：C18H8Cl2F4N4O
ExactMass: 442.0
Molecular Weight: 443.18
Elemental Analysis: C, 48.78; H, 1.82; Cl, 16.00; F, 17.15; N, 12.64; O, 3.61
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